Assessment of Her-2/neu gene amplification status in breast carcinoma with equivocal 2+ Her-2/neu immunostaining
نویسندگان
چکیده
منابع مشابه
Invasive pleomorphic lobular carcinoma, negative for ER, PR and Her/2neu--a case report.
Pleomorphic variant of lobular carcinoma is a recently described variant of invasive lobular carcinoma. It is reported to be positive for estrogen receptors and progesterone receptors and over express Her2/neu in most cases. We present here a case of invasive variant of pleomorphic lobular carcinoma with coexisting classic and pleomorphic variants of lobular carcinoma in situ along with focal d...
متن کاملHER-2 gene amplification in human breast cancer without concurrent HER-2 over-expression
BACKGROUND Testing for human epidermal growth factor receptor-2 (HER-2) in breast cancer is performed by either immunohistochemistry (IHC) or in situ hybridization (ISH). The growth factor receptor-bound protein-7 (GRB7) gene is in close proximity to HER-2 on chromosome 17q11-12 and codes a signal transduction molecule shown to be an independent adverse marker in breast cancer. METHODS HER-2 ...
متن کاملAnatomic Pathology / HER-2 GENE AMPLIFICATION IN BREAST CANCER
We compared fluorescence in situ hybridization (FISH), immunohistochemical analysis, immunocytochemical analysis, and relative quantification assays using polymerase chain reaction (PCR) as methods for estimating HER-2 gene amplification and protein overexpression in fine-needle aspirate (FNA) specimens and paraffin-embedded tissue samples from 49 cases of breast cancer. FISH can be performed s...
متن کاملCorrelation of HER 2/neu gene amplification with immunohistochemistry and other prognostic factors in breast carcinoma.
The purpose of this study was to determine relationship between HER-2/neu status and estrogen receptor, progesterone receptor, grade and age by comparing fluorescence in situ hybridization and immunohistochemistry. One hundred invasive breast carcinomas were reviewed and fluorescence in situ hybridization analysis was performed in all cases. Immunohistochemical scores showed a perfect concordan...
متن کاملHER-3 expression in HER-2-amplified breast carcinoma
AIM OF THE STUDY To determine whether the expression of HER-3 influences the survival of HER-2 positive patients with breast cancer (BC). MATERIAL AND METHODS In the present work, the expression of HER-3 in a group of 35 HER-2 positive patients with BC was studied by performing immunohistochemistry (IHC) in formalin-fixed paraffin embedded tissues. RESULTS Higher HER-3 status if estimated b...
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ژورنال
عنوان ژورنال: Journal of the Egyptian National Cancer Institute
سال: 2011
ISSN: 1110-0362
DOI: 10.1016/j.jnci.2011.07.006